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Contents

1.         Abstract
2.         Type of treatment
3.         Background
4.         Objectives
5.         Criteria for including studies
6.         Search strategy
7.         Methods
8.         Description of studies
9.         Methodological quality
10.       Results
11.       Discussion of Findings
12.       Conclusions
13.       References
 

1. Abstract
Low-back pain is a very common complaint. The cause of pain is non-specific in most people presenting with acute low-back pain but some do become chronic. Chronic low-back pain is a disabling condition, costly to both individuals and society.

Back pain is a condition for which chiropractic treatment is often recommended

Chiropractic is a health profession concerned mainly with problems with muscles, bones and their associated tissues. There is an emphasis on manual treatments including spinal manipulation or adjustment, and this is often combined with other therapies.

There is some evidence from one systematic review and 4 other studies, although not conclusive, that chiropractic treatment is as effective as other therapies for low back pain but this may be due to chance. There is very little evidence that chiropractic is more effective than other therapies.

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2. Type of treatment Chiropractic

3. Background
Low-back pain is a very common complaint, with the lifetime prevalence reported as ranging from 11% to 84%.(Walker 2000) The cause of pain is non-specific in about 95% of people presenting with acute low-back pain, with serious conditions being rare.(Hollingworth, Todd et al. 2002) Chronic low-back pain is a disabling condition, costly to both individuals and society.(Maniadakis and Gray 2000) 

Back pain is a condition for which chiropractic treatment is often recommended

Chiropractic is defined by the World Federation of Chiropractic (Chiropractic. 1999) as a health profession concerned with the diagnosis, treatment and prevention of mechanical disorders of the musculoskeletal system, and the effects of these disorders on the function of the nervous system and general health. There is an emphasis on manual treatments including spinal manipulation or adjustment, and this is often combined with physical therapy modalities, exercise programs, nutritional advice, orthotics, lifestyle modification and patient education. (Chapman-Smith 2000)

Chiropractic treatments are commonly used in developed countries by low-back pain sufferers. In Australia, consultation to a chiropractor is the second most sort out treatment for low-back pain, with 19% seeking chiropractic treatment. (Walker, Muller et al. 2004) This has been a consistent finding in other developed countries. A Cochrane review of spinal manipulative therapy (SMT) for low-back pain concluded that SMT was not superior to other effective treatments, but was more effective than placebo. (Assendelft, Morton et al. 2004) Sub-group analysis determined that the profession of the manipulator did not alter this result. While other recent systematic reviews for back pain have included chiropractic interventions, these reviews have tended to concentrate only on spinal manipulation, and have not specifically investigated chiropractic treatment. (Bronfort, Haas et al. 2004)

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4. Objectives
To investigate whether chiropractic treatment are effective in the treatment of low-back pain in adults; and whether they have less adverse effects than other treatments

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5. Criteria for including studies
Types of study: Published systematic reviews or double-blind randomised controlled trials of chiropractic treatments compared to other therapies or to no therapy; limited to the English language.

Types of participants: Adults (18 years) with non-specific low-back pain.

Types of intervention: Chiropractic as reported by the study author compared to any other treatment including ‘sham’ manipulations.

Types of outcome measure: Pain, disability/function, overall improvement, patient satisfaction and adverse effects.

Exclusions: Pathological causes of low-back pain (eg cancer, inflammatory arthritis), and low-back pain with nerve roots irritation.

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6. Search strategy
We searched the following databases in May 2006: AMED, The Cochrane Library, MEDLINE, and CINAHL from 1996.  We also checked the reference lists of publications retrieved by the search for further relevant studies.  We also searched the World Wide Web for any other relevant studies.

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7. Data Collection, Analysis and Development of Recommendations
We used the above search strategy to obtain titles and abstracts of studies that were potentially relevant to this review.  Where studies met the criteria for inclusion, they were assessed in full text.  The quality of each study was evaluated using the GATE criteria (http://www.health.auckland.ac.nz/population-health/epidemiology-biostats/epiq/) for the evaluation of RCTs and systematic reviews.  Where primary studies were included in a good quality systematic review, the systematic review was included rather than the individual primary studies. Where the systematic reviews included the same primary studies, the Cochrane review was used.

The overall quality of the body of evidence (including all the included studies) was graded according to the NZGG CAM levels of evidence system.

Relevant data were extracted from the studies selected for inclusion.

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8. Description of studies
 

Summary details of the studies included in the systematic review are as follows:

Study

Participants

Intervention & Comparison

Outcomes measured

Main result

Comment

Rupert

1985

Egypt

Unknown number of patients with acute or chronic low-back pain

Short lever manipulations

vs

Sham manipulations

Drugs and bed rest

Follow up 3 weeks

Pain

More reduction in pain with chiropractic treatment

Lacks sufficient detail

Quality score (Jadad*) 0/5

Waagen

1986

29 patients with low-back pain

Spinal adjustments

vs

Sham manipulations

2-3 treatments for 2 weeks

Function

Pain

More improvement of both outcomes with chiropractic treatment

Small sample size

Randomisation based on admittance number

Quality score (Jadad) 3/5

Bronfort

1989

21 patients with uncomplicated low-back pain of various duration

Chiropractic adjustments

vs

Medical treatment

Follow up 6 months

% of patients improved

No significant differences

Small sample size

Quality score (Jadad) 0/5

Meade

1990/1995

741 patients with uncomplicated acute or chronic low-back pain

Standard chiropractic care

vs

Physiotherapy (includes spinal manipulation)

Follow up 3 years

Oswestry score (disability)

Significant improvement with chiropractic treatment

Quality score (Jadad) 3/5

Sanders

1990

18 patients with acute low-back pain

Chiropractic adjustments 

vs

Sham adjustment

No treatment

Pre-post comparison after 1 treatment

Pain

β-endorphin level in blood

 

Significant improvement in pain with chiropractic treatment

Small sample size

No inter-group comparison

Debatable clinical relevance

No accurate data provided

Quality score (Jadad) 2/5

Herzog

1991

37 patients with sacroiliac pain for at least 1 month

Chiropractic adjustments 

vs

Back school

Follow up 4 weeks

Pain

Oswestry score

Joint mobility

Significant improvement with back school

Quality score (Jadad) 2/5

Pope/Hsieh

1992/1994

164 patients with chronic low-back pain

Chiropractic adjustments 

vs

soft tissue massage

TENS

Corset

Follow up 4 weeks

Pain

No significant differences

Quality score (Jadad) 3/5

Triano

1995

209 patients with various forms low-back pain

Chiropractic adjustments 

vs

Sham adjustment

Back education program

Follow up 4 weeks

Pain

Oswestry score

 

Significant improvement in Oswestry score with chiropractic treatment at 2 weeks

No ITT analysis

Quality score (Jadad) 5/5

Skagren

1997

323 patients with various forms low-back pain (n=253) and neck pain

Chiropractic care (mostly spinal manipulation)

vs

Physiotherapy (including spinal manipulation)

Follow up 6 months

Pain

Oswestry score

No significant differences

Quality score (Jadad) 2/5

Cherkin

1998

US

321 patients with uncomplicated acute back pain

Chiropractic spinal manipulation

vs

Physiotherapy (McKenzie) both maximum 9 sessions in 1 month

Educational booklet

Follow up 2 years

‘Bothersomeness’ of symptoms scale

Roland disability scale

Direct costs

No significant differences at end of treatment phase

Quality score (Jadad) 2/5

Giles

1999

77 patients with chronic spinal pain

Chiropractic spinal manipulation (6 treatments over 3-4 weeks)

vs

Oral tenoxicam and ranitidine (?dose)

Acupuncture (6 treatments over 3-4 weeks)

Follow up  3-4 weeks

Functional disability

Pain intensity and frequency

No significant differences

Study stopped early

Quality score (Jadad) 3/5

Bronfort

2000

20 patients with acute or chronic sciatica

Chiropractic care

vs

medical care

Epidural steroid injections

Follow up 12 weeks

Disability

Pain

Medication use

Satisfaction

Healthcare utilisation

No significant differences

Small sample size

?pilot study

Quality score (Jadad) 3/5

*0=poor quality, 5=good quality

Summary details of the RCTs are as follows:

Study

Participants

Intervention & Comparison

Outcomes measured

Main result

Comment

Hsieh

2002

US

200 self-referred adults with sub acute low back pain

Mean age 48.4±13.7 years

 

17 women, 35 men

Back school vs

Myofascial therapy

Chiropractic

Combined myofascial therapy and chiropractic

For 3 weeks

Pain

Activity

All four groups showed significant improvement in pain and activity scores after 3 weeks of care, but did not show further significant improvement at the 6-month follow-up assessment. No statistically significant between-group differences were found either at the 3-week or 6-month reassessments.

Assessor blinded

Drop out rate 8% at 3 weeks and 11% at 6 month follow up.

No way to determine weather the effect is due to the natural history of back pain or a placebo effect

Hoiriis

2004

US

192 self-referred adults (21-59 years) with subacute low back pain

Mean age 41.9±9.9 years

67 women, 89 men

Chiropractic with placebo medicine

vs

Muscle relaxants with sham chiropractic

Placebo medicine with sham chiropractic

7 visits over two weeks

Pain

Oswestry score

Zung depression scale

Global impression of severity

4 week follow up

Baseline values, except GIS, were similar for all groups. When all subjects completing the protocol were combined (N = 146), the data revealed pain, disability, depression, and GIS decreased significantly (P <.0001); lumbar flexibility did not change. Statistical differences across groups were seen for pain, a primary outcome, (chiropractic group improved more than control group) and GIS (chiropractic group improved more than other groups). No significant differences were seen for disability, depression, flexibility, or acetaminophen usage across groups.

Double blind

Drop out rate 17.2% at 2 weeks and 24% at 4 weeks

No long term follow up

 

Hurwitz

2002

US

681 adults with low back pain

Mean age 51.0±16.7 years

52% women, 48% men

Chiropractic treatment

vs

Chiropractic plus physical modalities

Medical care

Medical care plus physical modalities

For 6 months

Pain

Disability

 

The mean changes in low back pain intensity and disability of participants in the medical and chiropractic care-only groups were similar at each follow-up assessment (adjusted mean differences at 6 months for most severe pain, 0.27, 95% confidence interval, -0.32-0.86; average pain, 0.22, -0.25-0.69; and disability, 0.75, -0.29-1.79). Physical therapy yielded somewhat better 6-month disability outcomes than did medical care alone (1.26, 0.20-2.32).

Blind assessment

Drop out rate <1% at 2 weeks, 1% at 6 weeks and 4% at 6 months

9. Methodological quality
The included studies were evaluated using the GATE criteria. The systematic review was of good quality. The included studies varied in methodological quality from poor to good. Two RCTs were of good quality and the other Fair.

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10. Results
The systematic review (Ernst and Canter 2003) found 12 relevant studies published between 1981 and 2000 which varied in methodological quality  6 fair to good and 4 poor). There was a lot of variation in the population (acute, chronic or mixed back pain with or without sciatica), in the interventions and comparisons and follow-up periods. The sample size was below 50 in 5 studies and unknown in one. Most did not have any power calculations and adequate follow-up was seen in only 4 studies.

The results were highly variable as well. Some small or moderate benefit of chiropractic treatment over comparison treatments was reported in 5 studies. No benefit was reported in 6 studies and chiropractic was less beneficial than back school in 1 study. There was no indication that chiropractic treatment was more effective in any particular type of low back pain (eg acute vs chronic).

All 4 studies sham chiropractic treatment as a comparison found chiropractic more effective.

One out of 4 studies found that chiropractic treatment was more effective than medication. This one was of poor quality.

No study found that chiropractic treatment was more effective than massage therapy, TENS, corset, education, or acupuncture.

Only one of 3 studies demonstrated that chiropractic was more effective than physiotherapeutic exercise.

The authors conclude that there is little evidence that chiropractic treatment is an effective treatment for low back pain or that it is more beneficial than other treatments.

One of the RCTs (Hsieh, Adams et al. 2002) which compared 4 treatments (back school, myofascial therapy, chiropractic and combined myofascial therapy and chiropractic) in patients with subacute low back pain found no difference between any group except combined therapy and myofascial therapy at 3 weeks. However back school, chiropractic and combined therapy were equally effective at reducing pain and increasing activity scores. There is no way to demonstrate that the effect of these therapies is different from no treatment

Twenty-three patients reported adverse events: 7 in the combined group, 6 in the chiropractic group, 4 in the myofascial group and 6 in the back school group. Most of these were short periods of worsening symptoms except one in the myofascial group experienced tinnitus.

An RCT (Hoiriis, Pfleger et al. 2004) which compared chiropractic with muscle relaxants and placebo found a significant reduction in pain for all groups (p<0.0001) over 4 weeks. There was also a significant improvement of pain in the chiropractic group compared to the control group at both 2 and 4 weeks (p=0.0301, p=0.0321). There was a significant decrease in the disability scores for all groups (p<0.001) but no difference between the groups. The same was found in the depression score. Global impression of severity decreased significantly for all groups (p<0.0001) and the chiropractic group improved more than the other two groups (p<0.05).

An RCT (Hurwitz, Morgenstern et al. 2002)which compared chiropractic treatment with chiropractic treatment plus physical modalities and medical care and medical care plus physical modalities in adults with low back pain found all groups had a significant reduction in pain at all assessment times (p<0.001). There were no differences between the groups in pain reduction. A similar result was found in improvement of disability.

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11. Discussion of Findings
The systematic review is complex and confusing however there appears to be some evidence, although not conclusive, that chiropractic treatment is as effective as other therapies but this may be due to chance. There is very little evidence that chiropractic is more effective than other therapies.

One RCT (Hsieh, Adams et al. 2002) found that for subacute back pain, combined chiropractic and myofascial therapy was as effective as either therapy alone. This study was of fair quality and as there was no placebo group, it is difficult to determine whether these therapies are more effective than no treatment.

One RCT (Hoiriis, Pfleger et al. 2004) found that for subacute back pain chiropractic was more beneficial than in reducing pain than placebo and more beneficial than placebo or muscle relaxants in reducing a global impression of severity.

An RCT (Hurwitz, Morgenstern et al. 2002) found that chiropractic treatment and medical care were similar in their effectiveness. There was a possible small benefit of physical therapy in reducing disability compared to medical care.

Adverse effects of chiropractic treatment were only reported in one RCT, these were mainly short periods of worsening symptoms. However other reports have described frequent mild adverse effects as well as more serious complications. For information about contraindications and possible adverse effects see:

http://www.webmd.com/content/article/4/1680_50518.htm

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12. Conclusions
There is level 3 evidence that chiropractic treatment is as effective as other treatments for low back pain.

There is level 2 evidence that chiropractic treatment helps to reduce acute low back pain

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13. References

Assendelft, W. J., S. C. Morton, et al. (2004). "Spinal manipulative therapy for low back pain. [Review] [105 refs]." Cochrane Database of Systematic Reviews 1.

Bronfort, G., M. Haas, et al. (2004). "Efficacy of spinal manipulation and mobilization for low back pain and neck pain: a systematic review and best evidence synthesis. [Review] [144 refs]." Spine Journal: Official Journal of the North American Spine Society 4(3): 335-56.

Chapman-Smith, D. (2000). The Chiropractic Profession. 2006. www.chiropracticreport.com/chiropractic.htm

Chiropractic. W. F. o. (1999). WFC Policy Statement, A General Dictionary Definition of Chiropractic. Assembly of the World Federation of Chiropractic, Auckland, New Zealand. http://www.wfc.org/website/WFC/website.nsf/WebPage/Home?OpenDocument&ppos=1&spos=0&rsn=y&Language=EN

Ernst, E. and P. H. Canter (2003). "Chiropractic spinal manipulation treatment for back pain? a systematic review of randomised clinical trials." Physical Therapy Reviews 8(2): 85-91.

Hoiriis, K. T., B. Pfleger, et al. (2004). "A randomized clinical trial comparing chiropractic adjustments to muscle relaxants for subacute low back pain." Journal of Manipulative & Physiological Therapeutics 27(6): 388-98.

Hollingworth, W., C. J. Todd, et al. (2002). "Primary care referrals for lumbar spine radiography: diagnostic yield and clinical guidelines.[see comment]." British Journal of General Practice 52(479): 475-80.

Hsieh, C. Y., A. H. Adams, et al. (2002). "Effectiveness of four conservative treatments for subacute low back pain: a randomized clinical trial." Spine 27(11): 1142-8.

Hurwitz, E. L., H. Morgenstern, et al. (2002). "A randomized trial of medical care with and without physical therapy and chiropractic care with and without physical modalities for patients with low back pain: 6-month follow-up outcomes from the UCLA low back pain study.[see comment]." Spine 27(20): 2193-204.

Maniadakis, N. and A. Gray (2000). "The economic burden of back pain in the UK." Pain 84(1): 95-103.

Walker, B. F. (2000). "The prevalence of low back pain: a systematic review of the literature from 1966 to 1998. [Review] [76 refs]." Journal of Spinal Disorders 13(3): 205-17.

Walker, B. F., R. Muller, et al. (2004). "Low back pain in Australian adults. health provider utilization and care seeking." Journal of Manipulative & Physiological Therapeutics 27(5): 327-35.

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Date prepared:          1 July 2006

 

 
 
 

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